Unlocking Energy Expenditure for Cardiometabolic Therapies

Show notes

Watch the full video on YouTube to hear EASD TV host Vivienne Parry speak with Zachary Gerhart-Hines, recipient of this year's EASD Minkowski Prize, about his research into the neurokinin 2 receptor and energy expenditure.

The conversation explores why targeting energy expenditure complements current appetite-focused therapies, and how this pathway could deliver higher quality weight loss by reducing fat mass while preserving muscle. Zachary also discusses the surprising discovery that the pathway regulates appetite without nausea, its parallels with GLP-1 and amylin mechanisms, and the path from lab discovery to a spin-out with first-in-human studies on the horizon.

He also reflects on the future of precision and personalised treatment, with a growing set of tools to match the right therapy to the right patient.

Explore Prof. Zachary Gerhart-Hines's portrait. 

To hear the full Minkowski Lecture, watch it on the EASD platform.

For more episodes, visit our podcast archive.