Diabetes Insights - Breakthroughs and Innovators

In this episode, Prof. Chantal Mathieu and Prof. Francesco Dotta discuss two major European clinical trials presented at the EASD Annual Meeting: MELD-ATG and VERA-T1D.

Both studies were conducted through the INNODIA consortium, a large European collaboration aimed at identifying biomarkers and testing new disease-modifying therapies for type 1 diabetes.

The VERA-T1D trial investigated verapamil, a long-established cardiovascular drug, for its potential to preserve beta cell function after diagnosis. While the study narrowly missed its primary endpoint, the results provide important insights into disease heterogeneity and future combination therapies.

The MELD-ATG trial used an innovative adaptive trial design to identify...

In this episode, members of the EASD Committee on Clinical Affairs (CCA) discuss how clinical guidance is developed, reviewed and translated into real-world practice. CCA Chair, Prof. Richard Holt and Prof. Anne Peters explore the production of consensus reports, expert opinion documents and the EASD’s new guideline programme.

They discuss the first EASD guideline on diabetes distress, the upcoming guideline on continuous glucose monitoring in type 2 diabetes, and updates to the Type 1 diabetes consensus report. The conversation also highlights the critical role of patient involvement, public consultation and policy engagement in ensuring that guidance improves care across Europe...

In this episode, Prof. Nita Forouhi (University of Cambridge) and Prof. Michael Lean (University of Glasgow) explore the science behind nutrition, weight loss and type 2 diabetes remission. They discuss the role of ultra-processed foods, meat consumption and the importance of whole-food, minimally processed diets.

The conversation highlights groundbreaking research showing that substantial, intentional weight loss can reverse type 2 diabetes by reducing fat in organs like the liver, pancreas, and heart, restoring insulin sensitivity and pancreatic function.

They also tackle how to communicate evidence-based messages amid a flood of misinformation, and the importance of patient-centred research and guidance for...

In this episode, experts from the University of Amsterdam (Prof. J. Hans de Vries), the University of Newcastle (Prof. James A.M. Shaw) and Deakin University (Prof. Jane Speight) explore one of the most feared complications of type 1 diabetes: severe hypoglycaemia.

While advances in continuous glucose monitoring and automated insulin delivery have reduced severe episodes by around 40%, they have not eliminated the problem. The discussion examines why technology has limits, the challenges of impaired awareness and when transplantation may be considered for people with recurrent severe hypoglycaemia.

The conversation also highlights the profound psychological burden of hypoglycaemia; from trauma...