EASD 2025: Golden Anniversary - 50 years of attending the EASD Annual Meeting

00:00:00: Diabetes Insights, Breakthroughs and Innovators.

00:00:04: The EASD TV podcast

00:00:07: from the

00:00:07: annual meeting of the European Association for the Study of Diabetes.

00:00:13: Hello!

00:00:13: And welcome back to ESDTV Now.

00:00:16: one of great pleasures sitting in this seat is that you get talk to remarkable people.

00:00:23: I'm about introduce somebody who's Very remarkable, Eberhard Stadel.

00:00:28: And the reason he is so remarkable... ...is that today marks the fiftieth anniversary of his first attendance at EASD.

00:00:40: Eberhart you're very welcome.

00:00:42: I'm so pleased to see you!

00:00:44: So what was it like?

00:00:46: The very first time that you came to EAS D and presumably you were a young researcher then.

00:00:53: Thank you very much for this kind introduction.

00:00:57: Actually, it's a fantastic privilege having been able to more or less do a lifelong journey in doing research and clinical-oriented research bringing new hopes to patients but also get the questions back from the patient into the laboratory situation.

00:01:18: at that time in nineteen seventy five There was still a problem with diabetic ketoacidosis type one persons with diabetes and this was very serious condition at that time.

00:01:32: We were just learning, if you overcompensate what is wrong with the acidosis or blood glucose it's really dangerous for your brain to develop brain swelling and other complications.

00:01:47: And this was the type of work I was doing at that time, we had a really unit just looking after people with ketoacetaminesis... And where

00:01:57: was this unit?

00:01:57: This one in Munich.

00:01:59: my mentor was Professor Minert.

00:02:02: he was local organizer for ESD meeting in Munich way back in nineteen seventy-five

00:02:10: And did you present a paper then?

00:02:12: I presented the paper, which later on was also published in the ESD journal Dab et aloja with Sir George Alberti.

00:02:22: One of the beacons at that time... In

00:02:26: fact actually i bumped into George earlier today so i know he's here this meeting.

00:02:34: This is really raising an important point a few that it's not only doing research, but you're not doing this in isolation.

00:02:46: You meet so many wonderful colleagues and dedicated people, bright people... And actually its community type of process how we make the progress looking after people with diabetes really starting from their education point But then also going all the way back to a bench of the lab and to make new discoveries there.

00:03:12: And so I'm really very, very grateful having been able still have in contact with many of those contacts.

00:03:25: It's social connections exercise.

00:03:29: Now you were saying and I hope i'm not being indelicate in revealing that you are eighty three, look incredibly fit?

00:03:39: And You have taken the advice That you give to your own patients about exercise tell me about it.

00:03:47: Well It hasn't really changed.

00:03:50: we always need To use a package of management for people with diabetes And still in this day and age the foundation is appropriate lifestyle management.

00:04:04: This of course includes, particularly also physical exercise.

00:04:10: one my fuses when you prescribe all these fantastic new drugs.

00:04:15: they are getting better actually now reversing over type two diabetes.

00:04:21: But if you do that, we should have some linkage with the presentation of how many steps are doing every day.

00:04:29: So this is one aspect and there's fantastic tools but it remains a lifelong challenge to use all options in combination.

00:04:40: Living With Diabetes is about your whole life!

00:04:43: It isn't just about Your glucose, it's about your whole life.

00:04:47: and even if you manage to control your glucose.

00:04:50: You need to think of all those other things the exercise that watch you eat because they're just part of your healthy life?

00:04:59: Well I strongly believe in partnership between patient and his doctor.

00:05:06: there was some fashion at sometime be our own doctor.

00:05:10: Of course its very important doing their own thing but you shouldn't do it in isolation.

00:05:15: It's all with this feedback which is needed and of course everybody needs guidance, especially in type one diabetes.

00:05:26: I'm still seeing a few patients with that so i am also lifelong partner.

00:05:31: for many people This is fantastic privilege.

00:05:37: Everything has changed.

00:05:38: Well, I think we

00:05:42: are actually entering now a new era both in type one and type two diabetes.

00:05:47: For the first time especially in type-two diabetes We seem to have the possibility to reverse or work type II diabetes early on To really no more guys senior.

00:06:01: it's not just bringing it back to some pre-stage of diabetes.

00:06:05: Now, the real task is normalization or glycemia and this one aspect I was presenting here at this meeting fifty years later – the linkage with cancer.

00:06:21: It's next frontier in handling these cardiometabolic renal diseases that we expanded also looking after cancer, because this happens before the manifestation of type II diabetes.

00:06:36: So in pre-stages and it's on... The same risk factors so some kind a common soil which are driving manifestation of diabetes, driving complications of diabetes but they're also promote development of cancer.

00:06:57: The hyperinsulinemia early on in the pre-stages is some priming effect with massive accumulation of ectopic fat.

00:07:07: And this then, together with a change metabolism shifting at mitochondrial level from glucose fuel to lipid fuel or free fatty acid fuel, this triggers then oncogenic messengers on the background of this priming effect.

00:07:31: This is driven largely by hyperintelinema and the change in metabolism.

00:07:36: so a new tool or the new target, I should say.

00:07:41: In this day and age is really normalization of glucose in type two diabetes.

00:07:48: And in type one similarly we have much better... Of course practical therapy's not least a closed loop for hybrid close systems to get very close to normalization of glucose with the feedback of continuous glucose monitoring, which is also very important in type II diabetes.

00:08:14: But more than that, the immuno-intervention early on I was really lucky to be one of the first cyclosporinated to demonstrate that type I diabetes was an autoimmune disease.

00:08:30: And of course, it only works as long you use the drug.

00:08:35: So this has side effects but is a much improved situation with currently available drugs and also training cells to become eyelid cells that produce insulin.

00:08:48: so I think fifty years later there are fantastic hopes for further development.

00:08:55: Yes!

00:08:56: for the BBC and others.

00:08:58: And we've always been saying, for a very long time, you know, I let transplants... We will be able to cure type

00:09:05: one.".

00:09:05: And it always seemed to me three-to five years.

00:09:08: but when he got at the end of the five years It was another three or five years But actually were finally here with real possibility Of certainly delaying Type One And possibly even curing type one with some of these stem cell approaches.

00:09:27: Tomorrow

00:09:27: morning there will be a session on cure, quote, Type I diabetes and options are better than ever but still i think to really reasonable in that yes we should use the tools.

00:09:44: prolonging insulin secretion in type one is very important, but overall it's the lifelong challenge of normalization.

00:09:54: You've had a fantastically interesting life.

00:09:57: your curiosity for science of diabetes remains absolutely undimmed.

00:10:03: I know you have an enjoyable congress so far.

00:10:08: every joy in the rest of that program.

00:10:12: And thank you so much for coming along to talk with us, Thank You So Much!

00:10:18: and there will be more from EASD TV very soon.

00:10:36: And if you'd like to dive deeper, You can find plenty more information at EASD.org.